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The inducible caspase-9 suicide gene system as a ‘safety switch’ to limit on-target, off-tumor toxicities of chimeric antigen receptor T-cells.

机译：可诱导的caspase-9自杀基因系统作为“安全开关”来限制嵌合抗原受体T细胞的靶向，非肿瘤毒性。

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Tessa eGargett; Michael eBrown;
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1. A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization [J] . Drent Esther, Themeli Maria, Poels Renee, Molecular therapy: the journal of the American Society of Gene Therapy . 2017,第8期

机译：通过亲和优化降低CD38-嵌合抗原受体的靶脱肿瘤作用的合理策略
2. Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor [J] . Fisher Jonathan, Abramowski Pierre, Don Nisansala Dilrukshi Wisidagamage, Molecular therapy: the journal of the American Society of Gene Therapy . 2017,第5期

机译：使用仅促刺激的嵌合抗原受体避免靶向肿瘤活化
3. Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy [J] . Gross Gideon, Eshhar Zelig Annual Review of Pharmacology and Toxicology . 2016,第Null期

机译：T细胞嵌合抗原受体（CARs）在癌症治疗中的治疗潜力：抵消肿瘤的毒性，以安全地进行CAR T细胞治疗
4. The Influence of Vitamin D Receptor, Metallothionein 1A and 2A Gene Polymorphisms on the Lead Toxicity to the Sensory Nervous System in the Chronic Lead- Exposed Workers [C] . Hung-Yi Chuang Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：维生素D受体，金属硫蛋白1A和2A基因多态性对慢性铅暴露工人铅对感觉神经系统的毒性的影响
5. 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Antigen Independent Signaling of Chimeric Antigen Receptors [D] . Long, Adrienne Hart 2015

机译：4-1BB共刺激可改善嵌合抗原受体的抗原独立信号转导所致的T细胞衰竭。
6. The inducible caspase-9 suicide gene system as a safety switch to limit on-target off-tumor toxicities of chimeric antigen receptor T cells [O] . Tessa Gargett, Michael P. Brown 2014

机译：可诱导的caspase-9自杀基因系统作为安全开关以限制嵌合抗原受体T细胞的靶向非肿瘤毒性
7. The inducible caspase-9 suicide gene system as a 'safety switch' to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells [O] . Gargett T., Brown M. 2014

机译：诱导型caspase-9自杀基因系统作为“安全开关”限制嵌合抗原受体T细胞的靶向，非肿瘤毒性

The inducible caspase-9 suicide gene system as a ‘safety switch’ to limit on-target, off-tumor toxicities of chimeric antigen receptor T-cells.

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